😺 AI healthcare makes BANK

PLUS: AI helped write the Bar exam?!

Welcome, humans.

Two housekeeping items for today!

First up: we totally forgot the poll for Thursday Trivia last week. It’s down below so you can vote FOR REAL this time. Please forgive us: despite this newsletter being about AI, we are only human…

Second up: Our first new podcast episode is now live!

We cover A16z’s 2025 Top 100 Gen AI consumer apps report, detailing the most popular AI tools based on traffic and app downloads (and which ones are actually worth your time to check out).

Also, this is probably the first time many of you have seen Grant IRL (hi, I’m Grant, I write this every day!), so make sure to give it a view and a like if you, well, like it!‍‍

Top 100 Most Popular AI Apps Right Now!

If you DON’T like it, you can also let us know in the feedback poll at the end of this email and tell us why (I love getting roasted—if you’re too nice to do it yourself, have GPT do it for you!).

Here’s what you need to know about AI today:

AI healthcare companies raised millions and made strides against Alzheimer’s.
CA says AI helped write Bar exam questions.
Anthropic wants more AI transparency.
Microsoft Copilot adoption has been flat for a year.

Advertise in The Neuron here.

AI tackles confusing benefits, scary diagnoses, and a new breakthrough in Alzheimer's research

Epic Systems (MyChart)

This weekend, we started listening to the Acquired podcast's deep dive on Epic Systems, and it was, in a word, epic.

We're talking about the little-known healthcare tech giant behind the MyChart portal that 191M Americans use.

Some wild facts: 47 years old, no lost customers (mostly!), bootstrapped with $140K total, zero VC, never going public, and maybe worth $100B (privately held).

Oh, and their Wisconsin campus even has an 11,000-seat underground auditorium, because why not?

While Epic dominates hospitals, AI is tackling some other healthcare headaches:

Healthee ($50M raised): AI simplifying confusing employee health benefits.
Craif ($22M raised): AI analyzing urine miRNA to spot 7 cancers early.

Healthee is tackling the frustrating administrative layer between employers and employees, while Craif is going after the holy grail of early, non-invasive diagnostics. And both are betting heavily on AI to simplify, personalize, and potentially save lives (and money, obviously).

But AI's biggest impact might be deeper than that—changing how we understand disease itself.

Case in point: AI just cracked a piece of the Alzheimer's puzzle. UC San Diego scientists used AI (think AlphaFold, not ChatGPT) to reveal a hidden, disease-causing function in the PHGDH protein and identify a potential drug target that improved memory in mice.

This discovery sparked a solid discussion on Hacker News: What if AI analyzed everyone's anonymized health records? Imagine graphing a data set so large, with strong enough data, that you could spot disease indicators four years ahead of time?

Enter Epic's Cosmos database: a real-world trove of anonymized data from 295M patients and 15B encounters. It's the closest thing we have to that massive dataset vision. And yes, Cosmos IS already being used with AI:

Finding complex clinical patterns.
Training predictive models (like spotting deteriorating patients).
Powering clinical decision support (“Look-Alikes” for rare diseases).
Driving large-scale research.

Our take: The biggest healthcare breakthrough could be AI connecting biology to clinical care by analyzing massive datasets like Cosmos. While it primarily holds clinical info (not deep molecular data for every patient), applying AI can uncover patterns and insights humans miss, revolutionizing how we understand and treat diseases. Thanks, Judy!

We wrote a lot more about this on the website, so check it out!

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Prompt Tip of the Day

Here’s a thread of underrated uses of ChatGPT that’s worth a read.

Here’s the most useful 6:

Create a therapy “panel” with 6 different personas who debate with each other in the same chat.
Build a daily ADHD task manager that reminds you of priorities each morning.
Upload lab results to get plain-English medical explanations before doctor visits.
Turn random fridge ingredients into complete weekly meal plans with shopping lists.
Craft personalized skincare routines from your product collection, or workout plans with calorie and macro tracking.
Compare employer insurance plans with scenario-based recommendations (topical!).

Bonus points to the person who uses AI to help translate news stories into the appropriate reading level so their kid can understand them!

Treats To Try.

Rabbit internOS turns your requests into functional web tools, like math games for kids or interactive quizzes, with just a prompt (read more).
PageOn transforms your static presentations into rich, interactive pages that mix text, images, charts, and 3D models—free 7-day trial.
RightNow AI automatically profiles, detects bottlenecks, and optimizes CUDA kernels for peak GPU performance without requiring you to write code or have deep CUDA expertise (for AI devs—if you know, you know).
AI Presentation Narrator turns your presentations into narrated videos instantly, eliminating the need to record voiceovers yourself—free to try.
CreateWise edits your podcasts and automatically repurposes them into short videos, social posts, and show notes—free trial, then $49/month.
SImular browses the internet with you on your Mac, taking over mundane tasks from filling Amazon carts to checking tax status—free to try.
UXAuditNow analyzes your website's user experience and delivers specific improvements based on extensive research—free options available.
Someone made an MS Paint clone for the web browser, and as one reformed PC user now all in on Mac, did not realize how badly was missing this in my life.

See our top 51 AI Tools for Business here!

*This is sponsored content. Advertise in The Neuron here.

Around the Horn.

The above DeepSeek documentary from AI Explained is the best 34 minutes you can spend today (although if you’ve got 51 minutes, “AI godfather” Geoffrey Hinton is always a good hang). Enjoy!
Amazon eliminated the “Do Not Send Voice Recordings” privacy option from many Alexa devices, meaning all user voice data now automatically goes to the cloud for training Alexa+.
Microsoft hired DeepMind co-founder Mustafa Suleyman and his team in a $650M deal to reduce dependency on OpenAI, but internal evaluations suggested the gamble had not paid off, with Copilot subscribers stuck at 20M weekly users for the past year.
Dario Amodei (Anthropic CEO) argued that AI interpretability critically lags behind AI capabilities, presenting urgent risks as models become increasingly integrated into society, and set a goal to reliably detect most AI model problems through interpretability by 2027.
The California Bar Exam faced widespread criticism after the State Bar disclosed that 23 out of 171 scored multiple-choice questions were created using AI.
Anthropic researchers investigating AI consciousness found deep uncertainty among experts (who estimate current AI models are 0.15% to 15% likely to be conscious), but conclude this likelihood will increase as AI advances, suggesting we should prepare for potential moral implications of AI welfare.

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